Mechanical Stress Induces Lung Fibrosis via Midkine Signaling Pathway

    American journal of respiratory and critical care medicine, 2015.

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    Keywords:
    Lung injuryangiotensin-converting enzymemechanical ventilation

    Abstract:

    Lung protective ventilatory strategies have been widely used in patients with acute respiratory distress syndrome (ARDS), but ARDS mortality rate remains unacceptably high and there is no proven pharmacological therapy.Mechanical ventilation can induce oxidative stress and lung fibrosis, which may contribute to high dependency on ventilat...More

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