Hydrodynamic size-based separation and characterization of protein aggregates from total cell lysates

Maya Tanase,Valerio Zolla,Cristina C Clement,Francesco Borghi,Aleksandra M Urbanska,Jose Antonio Rodriguez-Navarro,Barbara Roda,Andrea Zattoni,Pierluigi Reschiglian,Ana Maria Cuervo,Laura Santambrogio

NATURE PROTOCOLS（2014）

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摘要

Intracellular protein aggregation is a hallmark of different pathological conditions. Hollow fiber flow field-flow fractionation, coupled with multiangle light scattering, can be used to separate and biophysically characterize cellular aggregates.

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关键词

Isolation, separation and purification, Protein aggregation, Analytical biochemistry, Molecular biophysics

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