An in vivo microdialysis characterization of the transient changes in the interstitial dialysate concentration of metabolites and cytokines in human skeletal muscle in response to insertion of a microdialysis probe.

•MD catheterisation of skeletal muscle causes a perturbation to tissue homeostasis.•Carnosine, glutamine and taurine dialysate concentrations are elevated for up to 2h.•A sustained elevation of IL-6 and IL-8 dialysate concentrations persist for 7h.•This response occurs during apparent stable glucose and lactate metabolism.