Evaluation of adaptive immune responses and heterologous protection induced by inactivated bluetongue virus vaccines.

Emmanuel Breard,Guillaume Belbis,Cyril Viarouge,Kyriaki Nomikou,Andy Haegeman,Kris De Clercq,Pascal Hudelet,Claude Hamers,Francis Moreau,Thomas Lilin,Benoit Durand,Peter Mertens,Damien Vitour,Corinne Sailleau,Stéphan Zientara

Vaccine（2015）

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摘要

•Evaluation of heterologous vaccinations efficiency against BTV-8 or 16 serotypes.•Sheep vaccinated with inactivated vaccines against BTV strains 2, 4, and 9.•Heterologous vaccines reduce viraemia and clinical scores after BTV-16 challenge.•Reductions of clinical signs and viraemia discussed after BTV-8 challenge.

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关键词

Bluetongue virus disease,Inactivated vaccines,Experimental infection,Heterologous challenges,Sheep

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