Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors.

Sharadha Subramanian,Abran Costales,Teresa E Williams,Barry Levine,Christopher M McBride,Daniel Poon,Payman Amiri,Paul A Renhowe,Cynthia M Shafer,Darrin Stuart,Joelle Verhagen,Savithri Ramurthy

ACS medicinal chemistry letters（2014）

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摘要

Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure-activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.

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关键词

CSF1R,MAP,RTKs,STKs,TKs,VEGF,colony stimulating factor-1 receptor,ras-mitogen activated protein kinase,receptor tyrosine kinases,serine threonine kinases,tyrosine kinases,vascular endothelial growth factor receptor

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