Antisense versus proopiomelanocortin mRNA reduces vascular risk in a murine model of type-2 diabetes following stress exposure in early post-natal life.

Alberto Loizzo,Santi M Spampinato,Andrea Fortuna,Stefano Vella,Fulvia Fabi,Paola Del Basso,Gabriele Campana,Stefano Loizzo

Peptides（2015）

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摘要

•Postnatal double stress applied to newborn male mice produces a type-2 diabetes model in adults.•The model is accompanied by endogenous ACTH–corticosterone hyperfunction.•Aorta from stressed mice shows altered responses to noradrenaline and acetylcholine tone regulation.•Adult aorta alterations are prevented by postnatal administration of antisense versus proopiomelanocortin mRNA.•Antisense prevents aorta stress damage through ACTH–corticosterone down-regulation.

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关键词

Antisense oligodeoxinucleotide,Aorta,Nitric oxide,β-Endorphin,Postnatal stress,Diabetes vascular complications

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