Fully automated carotid plaque segmentation in combined contrast-enhanced and B-mode ultrasound.
Ultrasound in Medicine & Biology(2015)
摘要
Carotid plaque segmentation in B-mode ultrasound (BMUS) and contrast-enhanced ultrasound (CEUS) is crucial to the assessment of plaque morphology and composition, which are linked to plaque vulnerability. Segmentation in BMUS is challenging because of noise, artifacts and echo-lucent plaques. CEUS allows better delineation of the lumen but contains artifacts and lacks tissue information. We describe a method that exploits the combined information from simultaneously acquired BMUS and CEUS images. Our method consists of non-rigid motion estimation, vessel detection, lumen–intima segmentation and media–adventitia segmentation. The evaluation was performed in training (n = 20 carotids) and test (n = 28) data sets by comparison with manually obtained ground truth. The average root-mean-square errors in the training and test data sets were comparable for media–adventitia (411 ± 224 and 393 ± 239 μm) and for lumen–intima (362 ± 192 and 388 ± 200 μm), and were comparable to inter-observer variability. To the best of our knowledge, this is the first method to perform fully automatic carotid plaque segmentation using combined BMUS and CEUS.
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关键词
Carotid plaques,Plaque segmentation,B-Mode,Contrast-enhanced ultrasound,Vessel detection,Lumen–intima segmentation,Media–adventitia segmentation
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