Direct factor Xa inhibitors (rivaroxaban and apixaban) versus enoxaparin for the prevention of venous thromboembolism after total knee replacement: A meta-analysis of 6 randomized clinical trials.

Guofeng Ma,Ruifeng Zhang,Xiaohong Wu,Dan Wang,Kejing Ying

Thrombosis Research（2015）

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摘要

•A total of 6 RCTs with 13,790 patients were included in this meta-analysis.•Direct Xa inhibitors were more effective for the prevention of VTE.•Comparable major bleeding existed between direct Xa inhibitors and enoxaparin.

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关键词

Venous thromboembolism,Factor Xa inhibitor,Rivaroxaban,Apixaban,Enoxaparin,Total knee replacement

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