5-O-Acyl plumbagins inhibit DNA polymerase activity and suppress the inflammatory response.

Takefumi Onodera,Isoko Kuriyama,Yuka Sakamoto,Moe Kawamura,Kouji Kuramochi,Kazunori Tsubaki,Atsushi Tabata,Hideaki Naganune,Yoshiyuki Mizushina

Archives of Biochemistry and Biophysics（2015）

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摘要

•5-O-Acyl plumbagins, a conjugation of plumbagin with fatty acids, were synthesized.•C22:6-acyl plumbagin potently inhibited the activity of mammalian DNA polymerase λ.•C22:6-acyl plumbagin suppressed TNF-α production induced LPS in cultured cells.•C22:6-acyl plumbagin reduced inflammation stimulated TPA in mouse ear.•These anti-inflammatory properties might be caused by DNA polymerase λ inhibition.

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关键词

5-O-Acyl plumbagins,C22:6-acyl plumbagin,DNA polymerase λ,Enzyme inhibitor,Anti-inflammation

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