Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum
NATURE NEUROSCIENCE(2015)
摘要
The authors use developmental changes in chromatin accessibility to identify thousands of enhancer elements that are active at different postnatal developmental stages in granule neurons of the cerebellum. Zic transcription factors were found to promote gene expression patterns key for neuronal maturation by binding to late-acting enhancer elements.
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关键词
differentiation,molecular neuroscience
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