Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop.

David Kirkland,Errol Zeiger,Federica Madia,Nigel Gooderham,Peter Kasper,Anthony Lynch,Takeshi Morita,Gladys Ouedraogo,Juan Manuel Parra Morte,Stefan Pfuhler,Vera Rogiers,Markus Schulz,Veronique Thybaud,Jan van Benthem,Philippe Vanparys,Andrew Worth,Raffaella Corvi

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2014）

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摘要

•EURL ECVAM Workshop on positive results in the Ames test is reported.•Data from public, regulatory agencies and company in-house archives were reviewed.•Prediction of carcinogenicity/in vivo genotoxicity based on mammalian cell tests.•Critical regulatory implications of preliminary results.•Consensus to construct a consolidated genotoxicity and carcinogenicity database.

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关键词

Genotoxicity in vitro,Genotoxicity in vivo,Positive Ames tests,Mammalian cell tests,Database,Carcinogenicity

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