A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

Baptiste Ronan, Odile Flamand, Lionel Vescovi, Christine Dureuil, Laurence Durand,Florence Fassy, Marie-France Bachelot, Annabelle Lamberton,Magali Mathieu,Thomas Bertrand, Jean-Pierre Marquette,Youssef El-Ahmad,Bruno Filoche-Romme,Laurent Schio,Carlos Garcia-Echeverria,Hélène Goulaouic,Benoit Pasquier

NATURE CHEMICAL BIOLOGY（2014）

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摘要

small-molecule inhibitor of the type III phosphatidylinositol 3-kinase, Vps34, binds the ATP binding pocket and prevents vesicle trafficking and autophagy.

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nature chemical biology, science

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