Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays

José-Manuel Molina-Molina,Macarena Real,Inmaculada Jimenez-Diaz,Hidaya Belhassen,Abderazzak Hedhili,Pablo Torné,Mariana F. Fernández,Nicolás Olea

Food and Chemical Toxicology（2014）

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摘要

•We investigated the agonist/antagonist activities of ZEN and its metabolites.•Interactions with hERα and hAR were studied by in vitro receptor-specific bioassays.•ZEN and its metabolites behaved as full hERα agonists in the E-Screen bioassay.•We found that all six compounds possess hAR-mediated antagonistic activity.•The metabolites ZAN, α-ZAL and β-ZAL were the most potent hAR antagonists.

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E2,MTT,AhR,CPP,CAR,DCC,DMSO,ERs,FBS,Flut,G418,hAR,hCG,hERα,hPXR,HSD,ICI,R1881,NRs,POPs,Proc,PE,rt,StAR,SRB,TCA,Vin,ZAN,ZEN,RAL,β-ZAL,β-ZEL,α-ZAL,α-ZEL

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