Expression of SCC-Ag and TK1 in locally advanced cervical carcinoma and the significance in treatment

Objective: To investigate the expression of SCC-Ag and TK1 in locally advanced cervical carcinoma and the significance in treatment. Methods: Serum samples were collected from 45 patients with locally advanced cervical carcinoma before and after treatment. Levels of SCC-Ag and TK1 were measured. Results: Positive rate of SCC-Ag was 68.89%. The expression of SCC-Ag was significantly associated with clinical stages, lymph node metastasis, and diameter of tumor (P<0.05), but not with histological grade (P>0.05). The positive rate of TK1 was 51.11%. The expression of TK1 was significantly associated with diameter of tumor, lymph node metastasis and histological grade (P<0.05), but not with clinical stages (P>0.05). The levels of SCC-Ag and TK1 were (18.92±4.43) ng ·mL -1 and (12.53±9.46) pmol ·L -1 before treatment, which were significantly reduced after treatment (3.51±0.92) ng ·mL -1 and (1.84±0.45) pmol ·L -1, P<0.05). There were significant differences of the levels of SCC-Ag and TK1 between patients with effective and ineffective treatment (P<0.05). The expression of SCC-Ag was not significantly correlated with TK1 in locally advanced cervical carcinoma. Conclusion: SCC-Ag and TK1 can be used for evaluating the effects of treatment and the prognosis in patients with locally advanced cervical carcinoma.