Vogt-Koyanagi-Harada syndrome: 5 cases report with clinical and neuroimaging features

Objective: To investigate the clinical and neuroimaging features of Vogt-Koyanagi-Harada syndrome (VKH). Methods: Cerebrospinal fluid (CSF), neuroimaging examination, clinical manifestation and pharmacotherapy features were investigated in 5 patients diagnosed as VKH. Results: All 5 patients were diagnosed as uveitis in the early stage of disease. All patients suffered "headache". Meningeal irritation sign was appeared in 3 cases. The MRI enhanced scan of all 5 cases showed abnormal enhancement of meninges. CSF examination showed increased leukocyte number ((4-196) × 10 6/L). All patients were alleviated with combination therapy of high dose of steroid with cyclophosphamide. Conclusions: VKH is a systemic disease that usually involving the uvea, central nervous system, internal ear and the skin. MRI and CSF examination are valuable for diagnosis. High dose of steroid combined with cyclophosphamide is an effective therapeutic strategy.