Microwave irradiation for accelerating synthesis of 5,6-diphenylimidazo[1, 2-a]pyrimidines based on isoflavones

Microwave irradiation was used to accelerate the cyclocondensation of isoflavones with 2-aminoimidazole to synthesize 5,6-diphenylimidazo[1,2-a]pyrimidines. A series of 17 new compounds were characterized by Fourier transform infrared, NMR, and elemental analysis. 5-(2-Hydroxyl-4-isopropoxyphenyl)-6-phenylimidazo-[1,2-a]pyrimidine was determined by x-ray diffraction. A variety of substrates can participate in the process with good yields and purities, making this methodology suitable for library synthesis in drug discovery.