Palladium-catalyzed C-H acetoxylation of 2-methoxyimino-2-aryl-acetates and acetamides.

Palladium-catalyzed C-H acetoxylation reactions of 2-methoxyimino-2-aryl-acetates and acetamides have been developed. These transformations feature excellent regioselectivity, wide substrate scope, and moderate to good yields. The product can be easily converted into naturally unprecedented alpha-amino acids in excellent yields.