Potent neutralization of influenza A virus by a single-domain antibody blocking M2 ion channel protein

    PloS one, Volume 6, Issue 12, 2011, Pages e28309-e28309.

    Cited by: 37|Bibtex|Views0|Links
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    Keywords:
    polymerase chain reactionkineticssurface plasmon resonancebiologyengineeringMore(13+)

    Abstract:

    Influenza A virus poses serious health threat to humans. Neutralizing antibodies against the highly conserved M2 ion channel is thought to offer broad protection against influenza A viruses. Here, we screened synthetic Camel single-domain antibody (VHH) libraries against native M2 ion channel protein. One of the isolated VHHs, M2-7A, spec...More

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