Identification and comparison of metabolites after oral administration of essential oil of Ligusticum chuanxiong or its major constituent ligustilide in rats.

PLANTA MEDICA(2008)

引用 26|浏览9
暂无评分
摘要
The rhizome of Ligusticum chuanxiong Hort. is a well-known traditional Chinese medicinal herb that is widely used to treat various vascular diseases. The aims of this Study were to identify and compare the metabolites in rats after the Oral administration of the essential oil of Ligusticum chuanxiong Hort. or its major constituent ligustilide monomer, and to explore the differences in the metabolism of the main active constituent monomer and the active constituent group. High-performance liquid chromatography with diode array detection was used to analyze the metabolites in the urine, feces, and bile of rats dosed with the essential oil or ligustilide. We observed clear differences in the metabolism of the essential oil and ligustilide. The other chemical constituents in the essential oil influenced the metabolism of the main active constituent monomer. Four metabolites in urine were separated, Purified, and identified as 5,7-dihydro- 6,7-diliydi-oxyligustilide (M1), 3,5-dihydroxy-3-butylphthalide (M2), 6,7-dihydro-6-hydroxy-7-sulfmethylligustilide (M3), and 5-hydroxy-3-butylidenephthalide (M4) by FT-ICR-MS and H-1-NMR. M2 and M3 are novel metabolites. Based oil the profiles of these metabolites, the pathway of ligustilide metabolism in rats is proposed.
更多
查看译文
关键词
Ligusticurn chuanxiong Hort.,Umbelliferae,essential oil,ligustilide,metabolism,FT-ICR-MS
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要