The synthesis of N-glycosyl-N '-pyrazolylmethylene aminothioureas under a 4 angstrom molecular sieve

Aseries of novel N-glycosyl-N′-pyrazolylmethylene aminothioureas (4a-4e, 5a-5e) were synthesized from N-glycosyl-N′-aminothioureas (2a-2d) and 4-formylpyrazole (3a-3e). Activated 4Å molecular sieves were adopted for dehydrated reagent to improve the reaction rate and yield. The structures of the new compounds were identified on the basis of IR, 1H NMR and MS spectra. Simultaneously, the compounds were detected by fluorescence spectrophotometer and had preferable fluorescence activity, so they can be selected as a kind of novel fluorescence labeled derivative of sugar.