Relationships between levels of antibody against oxidized low density lipoproteins and restenosis of coronary artery: Risk factor independent from age, sex, bodymass index hypertension, hyperlipemia and smoking history

Aim: To explore the relation between antibody against oxidized low density lipoproteins (ox-LDL) and clinical restenosis after percutaneous translumilar coronary angioplasty (PTCA) in patients without diabetes, clarify the meaning of predicting restenosis by ox-LDL antibody. Methods: The prospective study was undertaken in 41 non-diabetic subjects with unstable angina (UA), who were verified to be with single-lesion coronary disease by coronary artery opacification, their peripheral blood was taken before and after PTCA respectively, for detection of ox-LDL antibody, high sensitive C-reactive protein (hs-CRP), et al. These patients were followed-up for 6 months by clinical syndromes, including chest pain, electrocardiogram (ECG) of resting or symptom episoding, ECG of loading or myocardium perfusion image (MPI), coronary angiography (CAG) was adopted when necessary, clinical restenosis was judged synthetically. Results: By the end of six-month followed-up, clinical restenosis developed in 11 of 41 patients (26.8%). The level of CRP antibody in restenosis group preoperative was significantly higher compared with that in non-restenosis group (P = 0.03). There was no significant difference of CRP level in both group before and after the operation (P > 0.05). Compared with non-restenosis group, preoperative ox-LDL antibody level in restenosis group was significantly increased (P = 0.008). One week after operation, ox-LDL antibody level in restenosis group had increased by almost 1 time (P < 0.001), while the difference of non-restenosis group before and after the operation was not obvious (P > 0.05). Logistic regression analysis showed that elevated level of ox-LDL antibody was positively correlated significantly with restenosis, (OR = 2.663, CI of 95% for OR [ 1.149, 6.974], X2 = 16.688, P < 0.001), independent of age, gender, body mass index, hypertension, hyperlipemia lipid disorder, smoking history and hs-CRP levels. Conclusion: Preoperative level of ox-LDL antibody in nondiabetic subjects is a helpful predictive factor for development of clinical restenosis.