Synthesis And Biodistribution Of (Tcn)-Tc-99m(Chipdtc)(2) As A Potential Myocardial Perfusion Imaging Agent

The bis(N-cyclohexyl, N- isopropyl dithiocarbamato) nitrido technetium-99m complex [(TcN)-Tc-99m(CHIPDTC)(2)] (CHIPDTC: N- cyclohexyl, N-isopropyl dithiocarbamato) has been synthesized through a ligand- exchange reaction. The two- step procedure involved the initial reaction of (TcO4-)-Tc-99m with succinic dihydrazide (SDH) in the presence of stannous chloride as reducing agent and propylenediamine tetraacetic acid (PDTA) as complexant, followed by the addition of the sodium salt of N- cyclohexyl, N- isopropyl dithiocarbamate. The radiochemical purity (RCP) of the complex was 96 +/- 2% as measured by thin layer chromatography (TLC). No decomposition of the complex at room temperature (r. t.) was observed within a period of 6 hours. Its partition coefficient indicated that it was a lipophilic complex. The electrophoresis results showed that the complex was neutral. Biodistribution in mice indicated that the complex accumulated in the heart with high uptake and good retention. The heart/ blood, heart/ lung ratio was 6.28 and 1.35, respectively, at 60- minute post- injection, suggesting that it would be a potential myocardial perfusion imaging agent.