The antioxidative vitamins reduce atherosclerosis and protect DNA methylation of high-fat diet rabbits

Objective: To study the effect of antioxidative vitamins on high-fat diet rabbits in atherosclerosis and DNA methylation level. Methods: The microscope and the HPLC was used to compare the atherosclerosis and the DNA methylation level in the high-fat diet group and the antioxidative vitamins high-fat diet group of rabbit spleen. Results: The methylation level was higher and the atherosclerosis level was lower in antioxidative vitamins high-fat diet group of rabbits than that in high-fat diet group. And also there was a much less hyperplasia of smooth muscle cells and foam cells in the former group. Conclusion: The results suggested that antioxidative vitamins may effect the gene transcription by protecting DNA methylation, and may therefore reduce atherosclerosis. This may be another pathway of antioxidative vitamin reducing atherosclerosis caused by high-fat diet.