Synthesis and structures of tris(pyrazolyl)hydroborato complexes and their relevance to carbonic anhydrase
JOURNAL OF COORDINATION CHEMISTRY(1998)
摘要
A series of tris(pyrazolyl)hydroborato metal complexes [eta(3)-HB(3-R-1-5-R-2 pz)(3)]MX (R-1 = Ph, 2'-thienyl, R-2 = CH3, Ph; M = Ni, Cu, Zn, Cd; X = Cl-, NO3-, CH3COO-), and [eta(3)-HB(3-Ph-5-Mepz)(3)](3-Me-5-Phpz)Cu(PhCOO) (8) have been synthesized and characterized. Among them, the complexes [eta(3)-HB(3,5-Ph-2 pz)(3)]NiCl (3), [eta(3)-HB(3-Ph-5-Mepz)(3)]Cd(NO3)(THF) (4), and (8) were analyzed by X-ray structure methods, which revealed the bidentate coordination of NO3- in complex 4, and isomerized ligands in complex 8. As model compounds of carbonic anhydrase (CA), all of these structures were contrasted to that of the active site of CA; the chloride may be the closest model compound among them. The relationship between the coordination modes of NO3-, CH3COO-, and PhCOO- in the complexes and their IR spectra is also discussed.
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关键词
X-ray structures,tris(pyrazolyl)hydroborato,complexes,carbonic anhydrase
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