Neuroprotection by platelet-activating factor acetylhydrolase in a mouse model of transient cerebral ischemia.

Yijuan Wu,Lijuan Wang,Chengbo Dai,Guixian Ma,Yuhu Zhang,Xiong Zhang,Zhuohua Wu

Neuroscience Letters（2014）

引用 17|浏览7

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摘要

•It seems that human recombinant PAF-AH (rPAF-AH) may have neuroprotection in middle cerebral artery occlusion mice.•In these mice models we found that rPAF-AH might provide neuroprotection against ischemic injury.•Neuroprotection might be induced not only by decrease in MMP-2 and MMP-9 expression, but also by increased VEGF expression.

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关键词

MCAO,Matrix metalloproteinase,PAF-acetylhydrolase,Transient ischemia,Treatment,VEGF

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