Impact of polysomy 17 on HER2 testing of invasive breast cancer patients.

Yang Liu,Li Ma,Dequan Liu, Zhibing Yang,Chengang Yang,Zaoxiu Hu,Wenlin Chen, Zhuangqing Yang, Sijun Chen,Zhuoni Zhang

PubMed（2014）

引用 14|浏览11

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摘要

Polysomy 17 is a crucial cause of equivocal HER2 testing results by FISH, depending on which criterion (ratio vs. absolute number) is used for interpretation. Polysomy 17 cannot be an independent predictive factor for HER2 gene amplification or protein overexpression.

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关键词

Chromosome 17,breast cancer,fluorescence in situ hybridization (FISH),human epidermal growth factor receptor (HER2),immunohistochemistry (IHC),polysomy

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