K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

Kuzhuvelil B Harikumar,Jessie W Yester,Michael J Surace,Clement Oyeniran,Megan M Price,Wei-Ching Huang,Nitai C Hait,Jeremy C Allegood,Akimitsu Yamada,Xiangqian Kong,Helen M Lazear,Reetika Bhardwaj,Kazuaki Takabe,Michael S Diamond,Cheng Luo,Sheldon Milstien,Sarah Spiegel,Tomasz Kordula

NATURE IMMUNOLOGY（2014）

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摘要

IL-1 triggers IRF1 signaling, but the biological importance of this has remained uncertain. Kordula and colleagues show that an IL-1–IRF1 pathway is necessary for the selective induction of chemokines and sterile inflammation.

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nature immunology, science

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