Responsiveness to leukotriene D4 and methacholine for predicting efficacy of montelukast in asthma.

Wei-Jie Guan,Jin-Ping Zheng,Yi Gao,Cai-Yu Jiang,Yan-Qing Xie,Xu Shi,Zheng Zhu,Jia-Ying An,Xin-Xin Yu,Wen-Ting Liu,Nan-Shan Zhong

JOURNAL OF THORACIC DISEASE（2013）

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摘要

A lower responsiveness to leukotriene D-4 (LTD4) or higher LTD4/[methacholine (MCh)] potency ratio might suggest preferable outcomes of short-term montelukast monotherapy in terms of airway inflammation and lung function in asthmatic patients.

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关键词

Asthma,leukotriene D-4 (LTD4),leukotriene-responsive,leukotriene-unresponsive,methacholine (MCh),montelukast

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