Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A

Chenchen Feng,Xiaofeng Xie,Mengjun Wu,Chunzhu Li,Man Gao,Mingxia Liu,Xinming Qi,Jin Ren

Environmental Toxicology and Pharmacology（2013）

引用 23|浏览9

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摘要

•Tanshinone I facilitated the metabolism of AAI and reduced AAN.•Tanshinone I induced liver CYP1A expression.•Tanshinone I similarly increased the transcriptional activity of CYP1A1 and 1A2.

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关键词

Aristolochic acid,Kidney injury,Tanshinone I,CYP1A

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