Palladium-Catalyzed Methylation Of Alkynyl C(Sp)-H Bonds With Dimethyl Sulfonium Ylides

A novel palladium-catalyzed methylation protocol for the synthesis of methyl-functionalized internal alkynes has been established. This methylation method is achieved through a C(sp)-C(sp(3)) bond formation process and represents a new synthetic application of sulfonium ylides.