Catalytic asymmetric [8+2] cycloaddition: synthesis of cycloheptatriene-fused pyrrole derivatives.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2013)
摘要
Add a ring: A catalytic asymmetric [8+2] cycloaddition reaction of azaheptafulvenes with alkylidene malonates was developed. When employing catalytic amounts of a chiral N,N-dioxide L-NiII complex, the reaction afforded functionalized cycloheptatriene-fused pyrrole derivatives in excellent yields (up to 99 %), diastereoselectivities (>95:5 d.r.), and enantioselectivities (91-97 % ee) under mild conditions. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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关键词
asymmetric catalysis,azaheptafulvenes,cycloadditions,synthetic methods
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