Chemical constituents from Inula wissmanniana and their anti-inflammatory activities

Two new inositol derivatives, 4-acetate-1,2,3,5-tetrakis(2-methyl-2-butenoate) inositol ( 1 ) and 3-acetate-1,2,4,5-tetrakis(2-methyl-2-butenoate) inositol ( 2 ), one new flavonolignan 23- o -acetylsilychristin A ( 3 ), and one new thymol derivative 3-hydroxy-4-(2-hydroxy-1-methylethyl)benzoic acid ( 4 ), along with 13 known compounds, including ten flavonolignans ( 5 – 14 ) and three thymol derivatives ( 15 – 17 ) were isolated from the aerial part of Inula wissmanniana . The structures of new compounds were elucidated by detailed spectroscopic analysis, including HRESIMS and 2D-NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The anti-inflammatory activities of the compounds were tested against LPS-induced NO production in RAW 264.7 macrophages.