Ghrelin protects heart against ERS-induced injury and apoptosis by activating AMP-activated protein kinase.

Gai-Gai Zhang,Huai-Qiu Cai,Yan-Hui Li,Yu-Bin Sui,Jin-Sheng Zhang,Jin-Rui Chang,Ming Ning,Yang Wu,Chao-Shu Tang,Yong-Fen Qi,Xin-Hua Yin

Peptides（2013）

引用 53|浏览15

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摘要

•Ghrelin reduces ERS-induced injury and apoptosis in ISO-injured heart.•Ghrelin inhibits myocardial ERS by activating AMPK.•Ghrelin activates AMPK through GHS-R1a/CaMKK pathway in cardiomyocyts.

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关键词

Ghrelin,Heart,Endoplasmic reticulum stress,Apoptosis,AMP-activated protein kinase

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