MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2.

Ying Zhang,Lei Yang,Yuan-Fu Gao,Zhong-Min Fan,Xiao-Yi Cai,Meng-Yuan Liu,Xi-Rong Guo,Chun-Lin Gao,Zheng-Kun Xia

Molecular and Cellular Endocrinology（2013）

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摘要

•MiR-106b gain of function induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting Mfn2.•MiR-106b participates in TNF-α-induced mitochondrial injury and insulin resistance by regulating Mfn2.•These results suggest that miR-106b may represent a potential therapeutic target for the treatment of insulin resistance and type 2 diabetes.

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关键词

3′ UTR,ΔΨ,DHE,DMEM,ECL,ERR-α,FACS,GLUT4,IRS-1,miRNAs,miR-106b,Mfn2,mtDNA,PGC-1α,ROS,SDS-PAGE,T2DM,TNF-α

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