MiR-487a resensitizes mitoxantrone (MX)-resistant breast cancer cells (MCF-7/MX) to MX by targeting breast cancer resistance protein (BCRP/ABCG2).

Meng-Tao Ma,Miao He,Yan Wang,Xu-Yang Jiao,Lin Zhao,Xue-Feng Bai,Zhao-Jin Yu,Hui-Zhe Wu,Ming-Li Sun,Zhi-Guo Song,Min-Jie Wei

Cancer Letters（2013）

引用 95|浏览21

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摘要

•l MiR-487a can down-regulate BCRP expression in resistant MCF-7/MX breast cancer cells.•l MiR-487a can increase the cytotoxicity of MX in MCF-7/MX cells.•l MiR-487a resensitizes MCF-7/MX to MX by targeting BCRP.

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关键词

MiR-487a,BCRP,Multidrug resistance,Breast cancer

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