Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway.
Biochemical and Biophysical Research Communications（2013）
摘要
•TC, a CB2R specific agonist, stimulates SIRT1 activity by PKA/CREB pathway.•TC promotes PGC-1α transcriptional activity by increasing its deacetylation.•TC increases the expression of genes linked to FAO and promotes the rate of FAO.•The effects of TC in FAO are dependent on CB2R.•Suggesting CB2R as a target to treat diseases with lipid dysregulation.
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关键词
Fatty acid oxidation,Type 2 cannabinoid receptor (CB2R),Peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α),Sirtuin 1 (Sirt1),Trans-caryophyllene
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