A new route for the synthesis of 4-amino-5-fluoro-7-(2′-Deoxy- 2′-Fluoro-2′-C-methyl-β-d-ribofuranosyl)-1 H-pyrrolo[2,3-D] pyrimidine

Weidong Hu,Qinghua Yang,Shuyang Wang,Gang Huang,Yueteng Zhang,Jingjing Dong,Jinfeng Kang,Chuanjun Song, Jun Chang

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS（2013）

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摘要

A new route for the synthesis of the anti-HCV nucleoside analogue, 4-amino-5-fluoro-7-(2-deoxy-2-fluoro-2-C-methyl--d-ribofuranosyl)-1H-pyrrolo[2,3-d]pyrimidine 1, was developed.

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关键词

2-Deoxy-2-fluoro-2-C-methyl nucleoside,Vorbruggen procedure,anti-HCV activity

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