Beta-catenin CEACAM6 expression and prognostic value in elderly breast cancer tissues

Objective To detect characteristics of the elderly breast cancer tissue beta-catenin and the CEACAM6 protein and to explore the relationship between the two and clinical value. Methods As the observation group 82 cases of breast cancer in elderly postoperative specimens were selected from paraffin blocks, as a control group 60 cases of normal breast tissue were selected. The application of flow cytometry to detect the two groups in betacatenin and CEACAM6 protein, explore the beta-catenin and CEACAM6 in the expression of the difference of the clinical and pathological features, focus on their relevance. Amount of beta-catenin protein expression. Results The results of the observation group were significantly lower than the control group. CEACAM6 protein expression was significantly higher in the observation group. Beta-catenin and CEACAM6 protein expression and lymph node metastasis, vascular infiltration, the expression of ER was seen in observation group. PR is closely related to the expression of beta-catenin and CEACAM6. Observation group has a negative correlation, survival analysis showed that high expression of beta-catenin and CEACAM6 in the patient is poor prognosis. Conclusion Elderly breast cancer tissue beta-catenin and CEACAM6 expression, both on the progress of disease has an important role, the detection after beta-catenin and a CEACAM6 the expression may have a certain value in prognosis.