Pharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and robust UPLC-MS/MS method.
Journal of Pharmaceutical and Biomedical Analysis（2013）
摘要
•Establishment of a more sensitive and robust UPLC–MS/MS method.•PK of OMT and MT at low dose in rats.•Comparison of PK behavior between radix Sophorae tonkinensis extract and pure OMT.
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关键词
Radix Sophorae tonkinensis,Oxymatrine,Matrine,Pharmacokinetics,UPLC–MS/MS
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