Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation

Vabren L. Watts, Fernando M. Sepulveda,Oscar H. Cingolani,Alice S. Ho,Xiaolin Niu,Rosa Kim,Karen L. Miller,Koenraad Vandegaer,Djahida Bedja,Kathleen L. Gabrielson,Gerald Rameau,Brian O'Rourke,David A. Kass,Lili A. Barouch

Journal of Molecular and Cellular Cardiology（2013）

引用 38|浏览45

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摘要

•β3-AR regulates NOS signaling via differential nNOS phosphorylation in myocytes.•β3 induces NOS activity via modification of nNOS-Ser847 and -Ser1412.•β3-AR is mediated ROS suppression is regulated by Ser847 modulation.•β3-AR modulates nNOS-Ser847 and -Ser1412 phosphorylation via a Gi/o.•β3-mediated Ser1412 phosphorylation is Akt-dependent.

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关键词

Neuronal nitric oxide synthase,Reactive oxygen species,Hypertrophy,Heart failure,Beta3-adrenergic receptors

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