Polymorphisms in BER and NER pathway genes: effects on micronucleus frequencies among vinyl chloride-exposed workers in Northern China.

Qi Wang,Hong-shan Tan,Fang Zhang,Yuan Sun,Nan-nan Feng,Li-fang Zhou,Yun-jie Ye,Yi-liang Zhu,Yong-liang Li,Paul W Brandt-Rauf,Hua Shao,Zhao-lin Xia

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2013）

引用 17|浏览16

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摘要

•Results showed higher micronucleus frequencies in exposed workers than control.•Gene polymorphism was associated with higher level of induced chromosome damage.•Results exhibited combined effect of repair gene polymorphism and exposure dose.

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关键词

Vinyl chloride monomer,Chromosomal damage,Polymorphism,Base excision repair,Nucleotide excision repair

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