Molecular characterization of woodchuck CD4 (wCD4) and production of a depletion monoclonal antibody against wCD4.

Yinke Yang,Xiaoyong Zhang,Chunyan Zhang,Yuanqing Tao,Wei Fan,Zhongdong Wang,Hu Wang,Mengji Lu,Dongliang Yang,Melanie Fiedler,Baoju Wang

Molecular Immunology（2013）

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摘要

•The complete coding sequence of the woodchuck CD4 molecule was obtained and analyzed.•Two pAbs and four mAbs against wCD4 were produced and identified.•Anti-wCD4 mAb G2 effectively suppressed or depleted CD4 T cells in vitro and vivo.•This provides a basis for immune-related studies of HBV infection in woodchucks.

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关键词

HCC,HBV,WHV,CDS,pAb,mAb,PBMCs,wCD4,GST,IPTG,SDS-PAGE,ELISA,IF,HRP,OD,BHK-21 cells,FITC,IHC,ConA,CFSE,PerCP,FACS,CDI,nt,aa

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