Design, synthesis and biological evaluation of novel 3,4,5-trisubstituted aminothiophenes as inhibitors of p53-MDM2 interaction. Part 2.
Bioorganic & Medicinal Chemistry（2013）
摘要
Five series of novel 3,4,5-trisubstituted aminothiophene derivatives and analogs were designed and synthesized as p53–MDM2 binding inhibitors.
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关键词
3,4,5-Trisubstituted aminothiophenes,P53–MDM2 interaction,Anti-cancer,SARs
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