Phenylpropanoids and lignanoids from Euonymus acanthocarpus

A new phenylpropanoid derivative ( 1 ), along with five phenylpropanoids ( 2–6 ), two monoepoxy lignans ( 8–9 ), one bisepoxy lignan ( 10 ), two cyclolignans ( 11–12 ), six neolignans ( 7 , 13–17 ), two mixed lignan-neolignans ( 18–19 ), two lignan glycosides ( 20–21 ), and four flavonolignans ( 22–25 ), were isolated from the stems and twigs of Euonymus acanthocarpus . Compounds 2–3 , 6–8 , 12 , and 14–25 were obtained from Celastraceae family for the first time, and compounds 5 and 9 were isolated from Euonymus genus for the first time. All the compounds were tested for cytotoxicity against SK-OV-3 and MCG-803 human tumor cell lines. Compounds 3 , 10 , 12 , and 18 showed weak cytotoxicity against SK-OV-3 cell line, and compounds 3–4 , 10–13 , and 19 showed weak cytotoxicity against MCG-803 cell line.