Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors.

Ana Escribano,Ana I Mateo,Eva M Martin de la Nava,Daniel R Mayhugh,Sandra L Cockerham,Thomas P Beyer,Robert J Schmidt,Guoqing Cao,Youyan Zhang,Timothy M Jones,Anthony G Borel,Stephanie A Sweetana,Ellen A Cannady,Nathan B Mantlo

Bioorganic & Medicinal Chemistry Letters（2012）

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摘要

This letter describes the discovery and SAR optimization of tetrazoyl tetrahydroquinoline derivatives as potent CETP inhibitors. Compound 6m exhibited robust HDL-c increase in hCETP/hApoA1 double transgenic model and favorable pharmacokinetic properties.

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关键词

CETP inhibitor,HDL-c,Tetrahydroquinolines

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