Design, synthesis and evaluation of novel molecules with a diphenyl ether nucleus as potential antitubercular agents

A series of compounds with a diphenyl ether nucleus were synthesized and screened for antitubercular activity against Mycobacterium tuberculosis H37Rv, among which compound 6c was the most potent with MIC value of 4μg/mL. It was further found to be effective in attenuating the pathological changes caused by BCG infection in vivo.