Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury

Intensive care medicine, Volume 38, Issue 9, 2012, Pages 1548-1555.

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Keywords:
inflammationmechanical ventilationvolatile anesthetics

Abstract:

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter through activation of GABA receptors. Volatile anesthetics activate type-A (GABA(A)) receptors resulting in inhibition of synaptic transmission. Lung epithelial cells have been recently found to express GABA(A) receptors that exert anti-inflammatory properties. We hyp...More

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