Association study of C1qA polymorphisms with systemic lupus erythematosus in a Han population.

Objective: The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) in the C1qA gene region with systemic lupus erythematosus (SLE) in a Chinese Han population. Methods: Chinese SLE patients (n = 748) and ethnically- and geographically-matched healthy controls (n = 750) were genotyped for the C1qA region SNPs, rs172378 and rs665691, by using the Sequenom MassArray system. Results: The Chinese Han SLE patients and controls had statistically similar frequencies of alleles, genotypes, and haplotypes of C1qA polymorphisms. Moreover, no association signal was detected on different genetic models (additive, dominant, and recessive) or in SLE subgroups stratified by various clinical manifestations. Conclusions: The C1qA SNPs, rs172378 and rs665691, confer no genetic predisposition to SLE in a Chinese Han population. Lupus (2012) 21, 502-507.