Afferent drive elicits ongoing pain in a model of advanced osteoarthritis.

Alec Okun,Ping Liu,Peg Davis,Jiyang Ren,Bethany Remeniuk,Triza Brion,Michael H Ossipov,Jennifer Xie,Gregory O Dussor,Tamara King,Frank Porreca

PAIN®（2012）

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摘要

Monosodium iodoacetate (MIA)-induced ongoing pain depends on input from the joint; blockade of TRPV1 and TRPA1 channels fails to block MIA-induced ongoing pain.

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关键词

Spontaneous pain,Axotomy,Nerve injury,Anterior cingulate cortex,Negative reinforcement

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