Effective modulation of CD4 + CD25 +high regulatory T and NK cells in malignant patients by combination of interferon-α and interleukin-2

Guangxian Liu, Wuwei Yang,Mei Guo,Xiaoqing Liu, Naixiang Huang,Dingfeng Li,Zefei Jiang,Wenfeng Yang,Weijing Zhang,Hang Su,Zhiqing Liu,Tieqiang Liu,Dongmei Wang,Shan Huang,Bo Yao,Qiuhong Man, Lijuan Qiu,Xuedong Sun,Yuying Sun,Bing Liu

Cancer immunology, immunotherapy : CII（2012）

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摘要

Overinduced CD4 + CD25 +high regulatory T cells (Treg) and downregulated NK cells contribute to tumor-relevant immune tolerance and interfere with tumor immunity. In this study, we aimed to design a novel strategy with cytokine combination to correct the dysregulated Treg and NK cells in malignant patients. Initially, a total of 58 healthy individuals and 561 malignant patients were analyzed for their cellular immunity by flow cytometry. The average percentages of CD4 + CD25 +high /lymphocyte were 1.30 ± 1.19

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关键词

Cytokine,Treg and NK,Cellular immunity,Immunotherapy,Immune modulation

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